Failed To Open Stream

As soon as my main page (i.e. www.domain.com) loads, I get the below error messages. Can someone help me with this?

Warning: include(D:\hosting\member\mvlay\site1/) [function.include]: failed to open stream: Permission denied in D:\hosting\member\mvlay\site1\ray\modules\global\inc\header.inc.php on line 10

Warning: include(D:\hosting\member\mvlay\site1/) [function.include]: failed to open stream: Permission denied in D:\hosting\member\mvlay\site1\ray\modules\global\inc\header.inc.php on line 10

Warning: include() [function.include]: Failed opening 'D:\hosting\member\mvlay\site1/' for inclusion (include_path='.;C:\php5\pear') in D:\hosting\member\mvlay\site1\ray\modules\global\inc\header.inc.php on line 10