I've been running Nuke since late 2005 and never had hacker problems other than bots, spam bots and porn bots (forum areas, an occasional shout) which are more of an annoyance than a threat IMO. .htaccess edits control them to the most part but what i would suggest, if you're not already running, is Sentinel and or Protector.

They are the bomb ;o)

Both are part of my Nuke Platinum but are also stand alone mods you can get for free.